Improves joint flexibility It is necessary to provide connective tissues with nutrients, vitamins, minerals and fatty acids on a daily basis to maintain the flexibility of this osteoarticular mechanism and prevent cartilage wear. There are many natural solutions for maintaining good mobility. Chondroitin, glucosamine, MSM and boswellia are recognised for their effects on joints: Nutripure has selected the best active ingredients, which have been the subject of numerous scientific studies, to formulate Arthropure. √ Glucosamine and Chondroitin are two molecules naturally present in connective tissues such as cartilage, tendons, bones and skin. √ Glucosamine is a precursor of keratin, collagen and hyaluronic acid. The main role of glucosamine is the synthesis of glycosaminoglycans, polymers of sulphated and aminated sugars, which are key elements of cartilage structure. √ Chondroitin belongs to the glycosaminoglycan family. It helps ensure a certain elasticity and hydration of cartilage tissue by participating in the formation of synovial fluid. It may also help promote cartilage reconstruction by partially inhibiting certain enzymes that destroy cartilage. CARTILAGE PHYSIOLOGY Cartilage is a living tissue in perpetual renewal, even in the oldest people. It regenerates more slowly than tendon because it is not vascularised. Composed of 75 % water, 3 elements are fundamental to its repair and health: √ Chondrocytes repair cartilage by producing collagen and proteoglycans (proteins that make up the cartilage matrix). √ Collagen plays a structural role: it forms a network of solid fibres that give cartilage its shape and that retain the proteoglycans. √ Proteoglycans attract and retain water, creating a kind of "gel" that can compress and, above all, regain its shape after being deformed. Proteoglycans cluster onto a hyaluronic acid filament. The mesh of water-loving proteoglycans gives cartilage its elasticity but also its great resistance to pressure and its ability to absorb shocks. WHAT INGREDIENTS MAKE UP ARTHROPURE? 700mg of MSM , which provides sulphur essential to the formation of proteoglycans. The glycosaminoglycan binds to a protein via a sulphated group, thus forming the proteoglycan 600mg of Chondroitin sulphate Solabia® , an elementary molecule of glycosaminoglycans. Here, chondroitin sulphate of bovine origin, 90% pure, from the French laboratory, guaranteed free of infectious contaminants. 500mg of N-Acetyl-Glucosamine Kaneka® , an elementary molecule of glycosaminoglycans, whose acetylated form (N Acetyl) is part of the composition of hyaluronic acid. 250mg of Boswellin® Forte resin extract, whose boswellic acids are used for joint health in Ayurvedic tradition. Nutripure has selected a standardised extract containing 75% organic acids and 40% beta-boswellic acids (HPLC), guaranteed free of GMP, GMO, glyphosate, gluten and pesticides. 40mg of Vitamin C , which contributes to normal collagen formation for normal joint function MECHANISMS OF ACTION Boswellia AKBA and the boswellic acids (α-boswellic, β-boswellic and their acetylated derivatives) modulate enzymes and the inflammatory cascade in vitro: √ Inhibition of 5-lipoxygenase (5-LOX), a key enzyme in leukotriene synthesis. It is notably this 5-LOX activity that gives Indian frankincense its pain-relieving action √ Modulating action on 12-lipoxygenase (12-LOX) and 12-HETE-type derivatives. This is another pathway mediating the pro-inflammatory and vasomotor phenomenon. √ Effect of AKBA and KBA on cyclo-oxygenase 1 (COX-1), a key enzyme in the inflammatory response. Methylsulfonylmethane (MSM) Methylsulfonylmethane (MSM) is a sulphur-rich substance, a mineral essential to the formation of collagen in the skin, joints and blood vessels. In the joints, sulphur contributes to the synthesis of glycosaminoglycans (including chondroitin): √ Action on inflammation signals: reduction of a transcription factor such as the protein NF-ΚB and regulation of the expression of pro-inflammatory cytokines such as IL-1, IL-6 and TNFalpha (26) √ Action on oxidative stress. By modulating transcription factors, MSM may help regulate the balance of ROS and antioxidant enzymes. These biological mechanisms are yet to be explored through further studies. √ Action on symptoms. Scientific studies have shown the positive effect of MSM on joint pain and on the functional discomfort caused by osteoarthritis in daily life. In a randomised study of 50 patients with knee osteoarthritis, taking 1125 mg of MSM, 3 times a day, had an impact on perceived pain and on their physical function after 12 weeks compared to a placebo. Chondroitin Chondroitin sulphate belongs to the glycosaminoglycan family. Like glucosamine, it is an essential constituent of cartilage but also of connective tissues, the dermis, ligaments and tendons. √ Action on cartilage cells. In vitro, it is thought to contribute to cartilage structure and improve the anabolism/catabolism balance of the cartilage matrix. It may reduce pro-inflammatory factors and the resorption properties of osteoblasts in subchondral bone.
