Fisetin 500

Fisetin supplement, a key compound in anti-ageing research A fisetin supplement based on the latest research into anti-ageing √ Fisetin is a flavonol with exceptional biological characteristics. √ This polyphenolic compound is found in small quantities in mangoes, strawberries and certain medicinal plants. √ Unbeatable dosage of 500 mg of fisetin. √ Naturally extracted from the stem of Rhus succedanea and standardised to 98 % (maximum purity). Fisetin 500mg is the most powerful senolytic supplement ever placed on the market. It belongs to the large family of natural antioxidant polyphenols, such as quercetin, kaempferol or myricetin. It is designed to eliminate senescent cells scattered throughout the human body. These are “monstrous” cells that no longer participate in the body's functions, but persist in the tissue and parasitise healthy cells. Significant scientific research has shown that these senescent cells are directly associated with ageing and decline. With age, they become increasingly numerous. Fisetin also contributes to activating autophagy, a mechanism that serves to eliminate certain toxic elements accumulating in the cell. Its discovery by Professor Yoshinori Ohsumi was awarded the Nobel Prize in Medicine in October 2016. What is fisetin? Fisetin is a polyphenolic molecule found in fairly common fruits such as strawberry (160 mg/kg), apple (27mg/kg) and persimmon (10 mg/kg), as well as in certain medicinal plants. It has been described as having multiple beneficial biological activities including inhibition of cell proliferation, neuroprotection, bone protection and anti-inflammatory action. But the two most sensational properties remain its capacity to destroy senescent cells that parasitise the body and to activate the autophagy mechanism allowing cells to digest their own waste. Several studies have shown that it thereby extends longevity and reduces markers of senescence in humans. Its hydrophobic nature allows it to penetrate cells easily via the cell membrane. It then promotes the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins. One of its major advantages compared to other senolytics is that it reduces the fraction of senescent immune cells (T cells and NK cells), which amplifies its beneficial effect, since immune cells are themselves important for clearing senescent cells. An important study highlighted its senolytic properties and its impact on longevity: Fisetin is a senotherapeutic that extends health and lifespan. It also helps cells to get rid of their toxic waste by digesting it. This is the well-known mechanism of autophagy. Disruption of this mechanism (following mutations, for example) can cause chronic diseases such as cancer and neurological diseases. What are the mechanisms of action of Fisetin 500 mg? Fisetin is a rare product, capable of acting on three major phenomena associated with ageing: the multiplication of senescent cells, the inactivation of the autophagy process and the decline of neuronal communication. Fisetin also promotes neuron survival Numerous studies have shown that fisetin helps improve memory and concentration, protect neurons, and promote their growth. It is a compound capable of crossing the blood-brain barrier, then promoting communication between neurons in the hippocampus, a region of the brain associated with long-term memory. It strengthens the cohesion between the various neuronal protection factors and the energy maintenance of ATP levels in neurons.