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Vitamin D3 and K2: forms, doses and combinations

Vitamin D3 is the form most widely used in supplementation, and it is often paired with vitamin K2. This guide clarifies the forms, the conversion between µg and IU, and the rationale behind the D3+K2 combinations in the catalogue.
Vitamine D3 et K2 — couverture du guide praticien
  • Key conversion: 1 µg of vitamin D = 40 IU (25 µg = 1,000 IU). NRV: 5 µg (200 IU).
  • D3 sourced from lanolin or from lichen (vegan); K2 mostly as MK-7 (long half-life).
  • D and K carry separate EU claims (calcium and bone for D; blood clotting and bone for K).
  • Point of caution: vitamin K interacts with vitamin K antagonist anticoagulants, so check the manufacturer’s contraindications.

µg or IU: knowing how to convert

Labels state vitamin D in micrograms, often alongside the equivalent in international units: 1 µg = 40 IU, so 25 µg = 1,000 IU. The NRV is 5 µg (200 IU). That is the first thing to look for when reading a vitamin D product.

The forms of D3

Cholecalciferol (D3) comes as oily drops (often 1,000 IU per drop), capsules or softgels. It is sourced either from lanolin or from lichen for a vegan option. The product sheet states the source and the dose per serving.

Vitamin K2

K2 is mostly represented by the menaquinone MK-7 (produced by fermentation), which has a long plasma half-life and is sometimes supplied in standardised all-trans forms. MK-4 also exists and is used at higher doses.

Why combine D3 and K2

Many manufacturers combine D3 and K2 in a single serving: these are two fat-soluble vitamins with separate EU claims (D for calcium and bone structure, K for blood clotting and bone structure). The exact composition appears on the product sheet.

A regulatory point of caution

Vitamin K interacts with vitamin K antagonist anticoagulant treatments. Product sheets carry the contraindications supplied by the manufacturers; medical advice is essential for any patient concerned.

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